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American Ginseng


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What Is American Ginseng Used For?
The overall evidence for American ginseng’s potential health benefits is limited. However, the available pool of research is growing. Some research suggests this root could help treat:

  • Fatigue
  • Poor mental function
  • Diabetes
  • Cold & FLU
  • Clear
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So far, much of the evidence is from lab and animal studies. Human trials are in the earliest stages. They’ll reveal more about American ginseng’s safety and effectiveness.1


Preliminary research suggests American ginseng may fight fatigue. It has this in common with the more common Panax ginseng, a.k.a. Asian or Korean Ginseng.

A 2018 review of studies said American and Asian ginseng may be viable for treating fatigue from chronic illness. Researchers added that there’s a “critical need” for more and stronger trials.2

An older study said it appeared to improve cancer-related fatigue—and without side effects. The researchers called for more research into this treatment.3

Mental Function

Evidence is growing that American ginseng can improve mental function.

  • A 2020 study demonstrated more activity in some brain regions during processes using working short term memory.4
  • A 2019 review of research said it appears to enhance cognitive function and alertness.5
  • A 2019 study said American ginseng plus whole coffee fruit extract and Bacopa appeared to increase working memory.6
  • A 2015 study showed an increase in working memory in middle-aged people.7

Some studies noted improved mental function after just a single dose of American ginseng.


Maintaining normal blood sugar levels is important for managing and preventing diabetes.

A 2018 study found adding American ginseng to diabetes treatments helped keep blood sugars in line.8

Randomized, controlled trials done in 2019 and 2020—studies where participants were assigned to either a real or fake treatment group by chance—said American ginseng improved:

Ongoing research is looking at American ginseng use in treating pre-diabetes as well.11

Cold and Flu

American ginseng may offer protection against viral respiratory tract infections, including influenza, flu-like illnesses, and the common cold, according to a 2017 review.12

A 2020 analysis of research said American ginseng might be helpful in preventing and treating seasonal respiratory infections. However, researchers said the evidence wasn’t strong enough for firm conclusions.13

 Possible Side Effects

American ginseng is believed to be generally safe. Still, it may lead to side effects including:14

  • Restlessness
  • Insomnia
  • Anxiety
  • Mania
  • High blood pressure
  • Euphoria
  • Headache
  • Nosebleed
  • Vaginal bleeding
  • Vomiting and/or diarrhea
  • Low blood sugar

The long-term side effects of ginseng use aren’t known.

Drug interactions are possible. Unless your doctor has advised it, don’t take American ginseng with:14

  • Coumadin (Warfarin): It may reduce the drug’s effectiveness.
  • Depression medications called MAOIs: The combination may cause anxiety, headache, restlessness, and insomnia.
  • Blood sugar lowering drugs: It may low blood sugar too much.
  • Antipsychotic medications: It may increase effects and side effects.
  • Stimulants: It may increase the effects and side effects.

Pregnant women should not take American ginseng. It’s closely related to Panax ginseng, which is linked to possible birth defects.15


1 lb, 5 lbs

Supplement Facts

Serving Size 1 gram

Amount Per Serving
American Ginseng (Panax quinquefolium) root extract powder organic 1% ginsenosides 10 mg
Other ingredients: None

Dosage and Use
• Take one gram daily, before lunch and dinner, or as recommended by a healthcare practitioner.

• Do not purchase if outer seal is broken or damaged.
• When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

*These statements have not been evaluated by the FDA and are not intended to diagnose, treat, cure or prevent any disease or health condition.


  1. Mancuso C, Santangelo R. Panax ginseng and Panax quinquefolius: From pharmacology to toxicology. Food Chem Toxicol. 2017;107(Pt A):362–372. doi:10.1016/j.fct.2017.07.019
  2. Arring NM, Millstine D, Marks LA, Nail LM. Ginseng as a treatment for fatigue: A systematic review. J Altern Complement Med. 2018;24(7):624–633. doi:10.1089/acm.2017.0361
  3. Barton DL, Liu H, Dakhil SR, et al. Wisconsin Ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2. J Natl Cancer Inst. 2013;105(16):1230-1238. doi:10.1093/jnci/djt181
  4. White DJ, Camfield DA, Ossoukhova A, et al. Effects of Panax quinquefolius (American ginseng) on the steady state visually evoked potential during cognitive performance. Hum Psychopharmacol. 2020;35(6):1-6. doi:10.1002/hup.2756
  5. Kennedy DO. Phytochemicals for improving aspects of cognitive function and psychological state potentially relevant to sports performance. Sports Med. 2019;49(Suppl 1):39-58. doi:10.1007/s40279-018-1007-0
  6. Best T, Clarke C, Nuzum N, Teo WP. Acute effects of combined Bacopa, American ginseng and whole coffee fruit on working memory and cerebral haemodynamic response of the prefrontal cortex: a double-blind, placebo-controlled study [published online ahead of print, 2019 Nov 18]. Nutr Neurosci. 2019;1–12. doi:10.1080/1028415X.2019.1690288
  7. Ossoukhova A, Owen L, Savage K, et al. Improved working memory performance following administration of a single dose of American ginseng (Panax quinquefolius L.) to healthy middle-age adults. Hum Psychopharmacol. 2015;30(2):108-122. doi:10.1002/hup.2463
  8. Jenkins AL, Morgan LM, Bishop J, Jovanovski E, Jenkins DJA, Vuksan V. Co-administration of a konjac-based fibre blend and American ginseng (Panax quinquefolius L.) on glycaemic control and serum lipids in type 2 diabetes: a randomized controlled, cross-over clinical trial. Eur J Nutr. 2018;57(6):2217–2225. doi:10.1007/s00394-017-1496-x
  9. Jovanovski E, Lea-Duvnjak-Smircic, Komishon A, et al. Vascular effects of combined enriched Korean Red ginseng (Panax Ginseng) and American ginseng (Panax Quinquefolius) administration in individuals with hypertension and type 2 diabetes: A randomized controlled trial. Complement Ther Med. 2020;49:102338. doi:10.1016/j.ctim.2020.102338
  10. Vuksan V, Xu ZZ, Jovanovski E, et al. Efficacy and safety of American ginseng (Panax quinquefolius L.) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: a double-blind, randomized, cross-over clinical trial. Eur J Nutr. 2019;58(3):1237-1245. doi:10.1007/s00394-018-1642-0
  11. Feinberg T, Wieland LS, Miller LE, et al. Polyherbal dietary supplementation for prediabetic adults: study protocol for a randomized controlled trial. Trials. 2019;20(1):24. Published 2019 Jan 7. doi:10.1186/s13063-018-3032-6
  12. Mousa HA. Prevention and treatment of influenza, influenza-like illness, and common cold by herbal, complementary, and natural therapies. J Evid Based Complementary Altern Med. 2017;22(1):166–174. doi:10.1177/2156587216641831
  13. Antonelli M, Donelli D, Firenzuoli F. Ginseng integrative supplementation for seasonal acute upper respiratory infections: A systematic review and meta-analysis. Complement Ther Med. 2020;52:102457. doi:10.1016/j.ctim.2020.102457
  14. PennState Hershey: Milton S. Hershey Medical Center. American ginseng.
  15. Lewicka A, Szymański Ł, Rusiecka K, et al. Supplementation of plants with immunomodulatory properties during pregnancy and lactation-maternal and offspring health effects. Nutrients. 2019;11(8):1958. doi:10.3390/nu11081958

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