Berberine is a plant alkaloid that has been studied primarily for its bacteriostatic and bactericidal properties (Sun 1988). In patients with hepatic encephalopathy, oral berberine (600-800 mg/day) reduced blood concentrations of tyramine, an indirect neurotransmitter that is elevated in hepatic encephalopathy and can lead to some of its cardiovascular and neurological complications (Watanabe 1982). In a small trial of patients with chronic hepatitis B, C, or cirrhosis, berberine (1 g/day for 3 months) reduced circulating LDL and total cholesterol levels and liver enzymes (Zhao 2008).
Although berberine has been studied in human clinical trials and shown to have several metabolic benefits, concerns about long-term use of berberine have been raised on the basis of certain preclinical studies (Kysenius 2014; Mikes 1985; Mikes 1983). Some evidence suggests that long-term berberine use, especially at high doses, may impair particular aspects of cellular metabolism in specific types of cells.
Maintain healthy blood glucose levels already in the normal range*.
Support normal cholesterol and triglyceride levels*.
Support normal insulin sensitivity*.